Coden: Ijpnl6 Development of Surfactant Free Nanoparticles by a Single Emulsion High Pressure Homogenization Technique and Effect of Formulation Parameters on the Drug Entrapment and Release

The aim of this study was to prepare surfactant free Diclofenac sodium loaded ethyl cellulose nanoparticles by O/W single emulsion solvent evaporation high pressure homogenization technique.In the preparation of O/W single emulsion sodium alginate used as an emulsifying/stabilizing agent. Microparticles of nine different batches at different condition were prepared after that optimized batch was subjected to the high pressure Homogenizer for 3 cycles at 300 bar for the preparation of nanoparticles. The size of the nanoparticles was obtained in the range of 147.7nm to 256.6 nm .The maximum drugs loading of nanoparticles found about 90% and it showed about 66% of drug release in 12 hours. Physicochemical properties of these nanoparticles such as particle size, FESEM, X-RD and FTIR analysis were investigated. No drug-polymer interaction was observed in FTIR. FE-SEM images show that the particles are spherical and nanosized. Keyword: Diclofenac sodium, High pressure Homogenizer, Polymer, O/W emulsion.